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9號(hào)染色體開(kāi)放閱讀框72抗體

產(chǎn)品貨號(hào)：

BN41966R
中文名稱：

9號(hào)染色體開(kāi)放閱讀框72抗體
英文名稱：

Rabbit anti-C9orf72 Polyclonal antibody
品牌：

Biorigin

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產(chǎn)品規(guī)格

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BN41966R-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41966R-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41966R-200ul

200ul

￥3490.00

交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	C9orf72
中文名稱	9號(hào)染色體開(kāi)放閱讀框72抗體
別名	chromosome 9 open reading frame 72; CI072_HUMAN; MGC23980; Uncharacterized protein C9orf72.
研究領(lǐng)域	細(xì)胞生物染色質(zhì)和核信號(hào) 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來(lái)源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	53kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human C9orf72:391-481/481
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf72 gene product has been provisionally designated C9orf72 pending further characterization. There are two isoforms of C9orf72 that are produced as a result of alternative splicing events. Subcellular Location: Cytoplasm. Nucleus. Note=Detected in the cytoplasm of neurons from post mortem brain tissue (PubMed:21944778). Detected in the nucleus in fibroblasts (PubMed:21944779). Tissue Specificity: Both isoforms are widely expressed, including kidney, lung, liver, heart, testis and several brain regions, such as cerebellum. Also expressed in the frontal cortex and in lymphoblasts (at protein level). DISEASE: Defects in C9orf72 are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) [MIM:105550]. An autosomal dominant neurodegenerative disorder characterized by adult onset of frontotemporal dementia and/or amyotrophic lateral sclerosis in an affected individual. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. Note=Caused by a large expansion of a GGGGCC hexanucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci. SWISS: Q96LT7 Gene ID: 203228 Database links: Entrez Gene: 203228 Human Entrez Gene: 73205 Mouse Entrez Gene: 313155 Rat Omim: 614260 Human SwissProt: Q96LT7 Human SwissProt: Q6DFW0 Mouse SwissProt: Q66HC3 Rat Unigene: 493639 Human Unigene: 331544 Mouse Unigene: 233897 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.