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BN40751R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,ICC,Flow-Cyt,ELISA
BN40751R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,ICC,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | FoxP3 |
| 中文名稱 | 叉頭蛋白P3抗體 |
| 別 名 | AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID. |
| 研究領域 | 細胞生物 免疫學 轉(zhuǎn)錄調(diào)節(jié)因子 淋巴細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FoxP3:351-431/431 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Function: Probable transcription factor. Plays a critical role in the control of immune response. Subunit: Interacts with IKZF3. Subcellular Location: Nucleus (Potential). Post-translational modifications: Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1. DISEASE: Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain. SWISS: Q9BZS1 Gene ID: 50943 Database links: Entrez Gene: 50943 Human Entrez Gene: 20371 Mouse Omim: 300292 Human SwissProt: Q9BZS1 Human SwissProt: Q99JB6 Mouse Unigene: 247700 Human Unigene: 182291 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 叉頭蛋白3(FOXP3)是FOX蛋白家族成員之一,主要為T細胞轉(zhuǎn)錄蛋白，主要表達于T細胞+CD4+CD25,并調(diào)節(jié)該類T細胞的發(fā)育和功能. FOXP3的表達受轉(zhuǎn)化生長因子-β雌激素和糖皮質(zhì)激素等調(diào)節(jié),通過競爭性抑制活化T細胞核因子的轉(zhuǎn)錄活性而發(fā)揮作用.自身免疫性糖尿病患者體內(nèi)CD4+CD25+T細胞減少,誘導FOXP3的表達或過繼轉(zhuǎn)移CD4+CD25+T細胞有可能預防自身免疫性糖尿病 |
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