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產(chǎn)品規(guī)格
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BN40632R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN40632R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | Galectin 3 |
| 中文名稱 | 半乳糖凝集素3抗體 |
| 別 名 | Galectin-3; 35 kDa lectin; Carbohydrate binding protein 35; CBP 35; CBP35; GAL 3; GAL3; GAL-3; Galactose specific lectin 3; Galactose-specific lectin 3; Galactoside binding protein; Galactoside-binding protein; GALBP; Galectin3 internal gene,included; Galectin-3; Galectin3; GALIG; GBP; IgE binding protein; IgE-binding protein; L 31; L 34; L-34 galactoside-binding lectin; L31; Laminin binding protein; Laminin-binding protein; Lectin galactose binding soluble 3; Lectin galactoside binding soluble 3; Lectin L 29; Lectin L-29; Lectin, galactose binding, soluble 3; LGALS 3; LGALS2; LGALS3; LGALS3 protein; MAC 2 antigen; Mac-2; MAC2; Macrophage galactose-specific lectin; MGC105387;Galectin- 3; LEG3_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞凋亡 細(xì)胞粘附分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Galectin 3:181-250/250 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]. Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Subunit: Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Subcellular Location: Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Tissue Specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Similarity: Contains 1 galectin domain. SWISS: P17931 Gene ID: 3958 Database links: Entrez Gene: 3958 Human Entrez Gene: 16854 Mouse Omim: 153619 Human SwissProt: P17931 Human SwissProt: P16110 Mouse Unigene: 531081 Human Unigene: 248615 Mouse Unigene: 764 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Galectin-3是Galectin（半乳凝素）家族的一員，能識別糖蛋白和糖脂的特異性低聚糖結(jié)構(gòu)，參與多種生理和病理過程，包括細(xì)胞生長和凋亡、細(xì)胞黏附、新生血管形成和腫瘤浸潤與轉(zhuǎn)移等。Galectin-3在腫瘤的發(fā)生、發(fā)展及轉(zhuǎn)移中起重要作用。 Galectin-3在某些腫瘤組織中高表達(dá)，其在不同類型腫瘤，如結(jié)直腸癌、胃癌、胰腺癌、甲狀腺癌及肺癌等患者中的高表達(dá)水平，與低生存、腫瘤復(fù)發(fā)、預(yù)后差及對化療藥物敏感性降低相關(guān)對于某些腫瘤，Galectin-3有可能成為一個有價值的診斷標(biāo)志和治療靶點。 |
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